Heart failure & cardiomyopathies
Cardiorenal Disease Pathways and Treatment of Patients With Comorbid Heart Failure and Chronic Kidney Disease
Authors' conclusion
This study provides insights into the real-world trajectory of cardiorenal disease
Study context
- Population
- Adults (≥18 years) with comorbid heart failure (HF) and chronic kidney disease (CKD), indexed at first presentation with both; routinely collected health care data from England, Japan, Sweden and US4 countries · England 63,752 · Japan 128,861 · Sweden 43,612 · US 530,513
- Exposure
- CKD-first vs HF-first vs Simultaneous
- Outcome
- Chronological sequence of HF and CKD development, outpatient specialist care patterns and HF GDMT use before and after onset of both conditions
Methodological detailsreal-world data, multinational (England, Japan, Sweden, US)
- Real-world data
- Multinational (England, Japan, Sweden, US)
Main finding
As reported in the abstract
Disease progression pathway (England and US)
CKD-first
58%-61%
HF-first
31%-35%
Simultaneous
7%-8%
Observational data: associations, not effects.
Further findings
Outpatient appointments in the year before index
- General practitioners
- 61%-100%
- Nephrologists
- 4%-8%
HF guideline-directed medical therapy (GDMT) use
- Low before index and only mildly increased in the subsequent year, in all 4 countries
- Generally higher in HF-first than in other pathways
Original publication
Cardiorenal Disease Pathways and Treatment of Patients With Comorbid Heart Failure and Chronic Kidney Disease. JACC Heart Fail. Published 24 June 2026. doi:10.
Summarised from the published abstract; every number is checked against it