Cardio-oncology & otherMeta-analysis
Cardiorespiratory fitness in childhood cancer survivors: a systematic review and meta-analysis
- Systematic review and meta-analysis of cross-sectional studies
- fixed-effects meta-analysis
Authors' conclusion
Childhood cancer survivors have a marked reduction in cardiorespiratory fitness (7.1 mL/kg/min lower than CON) that may have important prognostic implications for their future risk of CVD and mortality.
Study context
- Population
- Childhood cancer survivors and age-matched non-cancer controls
- Participants
- 2,165 survivors · 18 studies
- Comparison
- Childhood cancer survivors vs age-matched non-cancer controls
- Childhood cancer survivors (CCS)n = 786
- Controls (CON)n = 1,379reference
- Outcome
- Cardiorespiratory fitness (V̇O2peak)
Pooled result
V̇O2peak
Weighted mean difference (WMD)
−7.08 mL/kg/min
95% CI −7.75 to −6.42
CCS vs CON
WMD −7.08 mL/kg/min (95% CI −7.75 to −6.42)
As reported in the abstract
Further pooled results
| Outcome | WMD (b.p.m.) (95% CI) | |
|---|---|---|
| Peak exercise heart rate · I2: 63%, n = 741 | −1.4 (−3.0 to 0.2) | |
| −4−202Difference, b.p.m. (linear scale) |
| Outcome | WMD (%) (95% CI) | |
|---|---|---|
| Resting LVEF · I2: 49%, n = 222 | −1.61 (−2.60 to −0.62) | |
| −4−202Difference, % (linear scale) |
| Outcome | WMD (mmHg) (95% CI) | |
|---|---|---|
| Resting SBP · I2: 25%, n = 184 | −3.8 (−5.7 to −1.9) | |
| −10−505Difference, mmHg (linear scale) |
| Outcome | WMD (bpm) (95% CI) | |
|---|---|---|
| Resting heart rate · I2: 55%, n = 262 | 4.9 (1.8–7.9) | |
| −50510Difference, bpm (linear scale) |
Original publication
Cardiorespiratory fitness in childhood cancer survivors: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 4 October 2024. doi:10.1093/eurjpc/zwae317
Summarised from the published abstract; every number is checked against it