Cardio-oncology & otherCross-sectional study
Cardiovascular disease burden at cancer diagnosis: temporal trends in a national study from England
- Serial cross-sectional study
- national
- linked primary care, cancer registry and hospitalisation records
Authors' conclusion
Pre-existing CVD at cancer diagnosis has increased substantially over 2 decades and is projected to affect nearly half of patients by 2050.
Study context
- Population
- Adults (≥18 years) diagnosed with the five most common cancers, England, 2001–2020
- Participants
- 773,590 adults
- Exposure
- 2016-2020 vs 2001-2005
- Outcome
- Age-standardised prevalence of pre-existing CVD at cancer diagnosis
Main finding
As reported in the abstract
Age-standardised prevalence of pre-existing CVD
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) subtypes and comorbidities
- Valvular disease, HF, AF and diabetes showed the largest subtype rises
Sequential modelling of risk factor domains
- Greatest attenuation of the temporal trend after adjustment for cardiometabolic conditions and chronic comorbidities
Projected prevalence of pre-existing CVD · 2050
- Approximately half of patients may present with pre-existing CVD at cancer diagnosis, if current patterns continue
Original publication
Cardiovascular disease burden at cancer diagnosis: temporal trends in a national study from England. Eur Heart J. Published 31 August 2026. doi:10.1093/eurheartj/ehag626
Summarised from the published abstract; every number is checked against it