Cardio-oncology & otherCohort study
Cardiovascular Disease in Males With Breast Cancer
- Population-based cohort study
- using linked administrative databases
- age-matched
Authors' conclusion
Males with BC have greater baseline cardiovascular risk than females with BC and cancer-free males but no increase in future CVD hazard after adjustment. This highlights the need for prioritizing cancer treatment in males with BC, with appropriate attention to CVD risk management.
Study context
- Population
- Males diagnosed with breast cancer (BC) in Ontario, Canada (1998–2021)683 males with BC matched to 2,049 females with BC, 687 males with BC matched to 2,061 cancer-free males · males with BC (vs female BC) 683 · females with BC 2,049 · males with BC (vs cancer-free males) 687 · cancer-free males 2,061
- Exposure
- Males with BC compared to females with BC and cancer-free males
- Female BCn = 2,049reference
- Cancer-free malesn = 2,061reference
- Outcome
- Hospitalization or emergency department visits for CVD
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Male BC vs Female BC
1.03(0.86–1.25)
Male BC vs Cancer-free males
1.00(0.84–1.19)
Observational data: associations, not effects.
Secondary outcomes
Pre-existing cardiovascular disease (CVD) and risk factors
- Males with BC had more prevalent pre-existing CVD and risk factors than both comparators
Cause-specific mortality
- Male BC was not associated with higher CVD mortality but was associated with higher cancer mortality relative to both comparator groups
Age
- median age
- 68 years [IQR: 59-77 years]
Original publication
Cardiovascular Disease in Males With Breast Cancer. JACC Adv. doi:10.1016/j.jacadv.2026.102937
Summarised from the published abstract; every number is checked against it