Cardio-oncology & otherCohort study
Cardiovascular Events After Hematopoietic Stem Cell Transplant
- Multicentre observational cohort study
- chart review
Authors' conclusion
The incidence of short-term CV events in HSCT recipients is relatively low. Long-term events were more common among allogeneic recipients and those with pre-existing CV comorbidities.
Study context
- Population
- Adult autologous or allogeneic hematopoietic stem cell transplantation (HSCT) recipients, 2008–2019median follow-up 2.3 years
- Participants
- 3,354 participants
- Exposure
- Allogeneic vs autologous HSCT
- Outcome
- Composite CV events (CV death, MI, HF, AF/flutter, stroke, sustained VT), short-term (≤100 days) and long-term (>100 days)
- Follow-up
- 100 days and 5 years
Main finding
As reported in the abstract
Cumulative incidence of CV events
100-day cumulative incidence
4.1%
5-year cumulative incidence
13.9%
Observational data: associations, not effects.
Further findings
Long-term CV events by transplant type · 5 years
P = 0.002
AF/flutter (most common cardiovascular (CV) event)
- 100-day incidence
- 2.6%
- 5-year incidence
- 6.8%
HF
- 100-day incidence
- 1.1%
- 5-year incidence
- 5.4%
Baseline CV comorbidities
- Associated with higher risk of long-term CV events
Original publication
Cardiovascular Events After Hematopoietic Stem Cell Transplant. JACC CardioOncol. Published 19 September 2023. doi:10.1016/j.jaccao.2023.07.007
Summarised from the published abstract; every number is checked against it