HypertensionSecondary analysis
Cardiovascular Health Change Patterns After Multifaceted Antihypertensive Intervention and Cardiovascular Outcomes
- Secondary analysis of the CRHC randomised trial
- post hoc analysis
- community-based
Authors' conclusion
In this large community-based randomized trial, a scalable intervention delivered by nonphysician providers reduced cardiovascular risk, with the benefit primarily driven by BP, alongside modest contributions from behavioral and metabolic domains.
Study context
- Population
- Rural Chinese participants with hypertension in the China Rural Hypertension Control Project
- Participants
- 26,700 participants
- Comparison
- Change patterns in cardiovascular health (CVH) (LS7 domains) after intensive blood pressure (BP) intervention and subsequent CV outcomes
- Primary endpoint
- Association of domain-specific CVH change patterns (BP, metabolic, behavioral) with subsequent CV outcomes
- Follow-up
- 36-48 months
Primary result
As reported in the abstract
CV outcomes by CVH change pattern
Hazard ratio (95% CI)
Improved CVH
0.71(0.54–0.89)
BP improvement plus behavioral or metabolic gains
0.57(0.30–0.84)
BP improvement alone
0.76(0.55–0.98)
Further findings
LS7 score · 36 months
| Comparison | net difference (95% CI) | |
|---|---|---|
| Intervention | 0.52 (0.38–0.66) | |
| −0.500.51Difference (linear scale) |
Mediation of CV risk reduction
- BP share of effect
- 67.5%
- Behavioral share of effect
- 8.0%
- Metabolic contribution minimal
BP and other LS7 components over time
- Sustained separation in BP between groups; only modest, less-differentiated changes in other components
Original publication
Cardiovascular Health Change Patterns After Multifaceted Antihypertensive Intervention and Cardiovascular Outcomes. J Am Coll Cardiol. Published 26 June 2026. doi:10.1016/j.jacc.2026.05.035
Summarised from the published abstract; every number is checked against it