Cardiovascular Health-Related Quality of Life in Cancer: A Prospective Study Comparing the ESC HeartQoL and EORTC QLQ-C30 Questionnaire
Authors' conclusion
The EORTC QLQ-C30 and ESC HeartQoL - assessing cancer and cardiovascular HRQoL - are both associated with increased mortality in cancer patients, with even greater stratification by combing both. Reduced HRQoL scores were associated with elevated cardiovascular biomarkers and decreased functional status.
Study context
- Population
- Patients with mostly advanced cancer and healthy controls
- Participants
- 290 vs 50
- Exposure
- ESC HeartQoL vs EORTC QLQ-C30 questionnaire
- Cancern = 290
- Controlsn = 50reference
- Outcome
- Health-related quality of life (HRQoL) summary scores (EORTC QLQ-C30 0-100 points; ESC HeartQoL 0-3 points)
Main finding
As reported in the abstract
| Group | EORTC QLQ-C30 | ESC HeartQoL |
|---|---|---|
| Cancer | 67 ± 20 | 1.8 ± 0.8 |
| Controls | 91 ± 11 | 2.7 ± 0.4 |
EORTC QLQ-C30
Cancer67 ± 20
Controls91 ± 11
ESC HeartQoL
Cancer1.8 ± 0.8
Controls2.7 ± 0.4
- Cancer vs Controls: P < 0.001 — EORTC QLQ-C30
- Cancer vs Controls: P < 0.001 — ESC HeartQoL
Observational data: associations, not effects.
Further findings
All-cause mortality by questionnaire cut-off (cancer patients)
| HR | P value | |
|---|---|---|
| EORTC QLQ-C30 <82.69 | 2.33 | P = 0.004 |
| ESC HeartQoL <1.50 | 1.85 | P = 0.004 |
| Outcome | HR | P value |
|---|---|---|
| All-cause mortality by questionnaire cut-off (cancer patients)Below both cut-offs vs Above both cut-offs | 3.60 | P < 0.001 |
- All-cause mortality by questionnaire cut-off (cancer patients): adjusted for sex, age, LVEF, NT-proBNP, high-sensitivity troponin T, cancer stage/type
- All-cause mortality by questionnaire cut-off (cancer patients): no differences by sex (p-interaction > 0.9)
Correlation between instruments
- Summary scores
- r = 0.76
- Physical subscales
- r = 0.81
- Emotional subscales
- r = 0.75
- All p < 0.001
Patients below both cut-offs
- Higher NT-proBNP and reduced physical function and activity
Original publication
Cardiovascular Health-Related Quality of Life in Cancer: A Prospective Study Comparing the ESC HeartQoL and EORTC QLQ-C30 Questionnaire. Eur J Heart Fail. Published 22 August 2023. doi:10.
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