Cardiometabolic & kidneyCross-sectional study
Cardiovascular-Kidney-Metabolic Medication Eligibility Across National Survey, Community-Based, and Ambulatory Healthcare Samples
- Cross-sectional study
- national survey, pooled community-based cohorts and ambulatory health care samples
- Data analyzed November 2024 to November 2025
Authors' conclusion
This study found that up to 61% of adults met FDA-approved indications for at least 1 of 3 novel CKM therapy classes.
Study context
- Population
- US adults in national survey, community-based cohort and ambulatory health care samples
- Exposure
- NHANES vs Pooled cohorts vs BIDMC vs MGB
- Pooled cohortsn = 30,929
- BIDMCn = 84,714
- MGBn = 362,485
- Outcome
- Medication class eligibility within each study sample
Main finding
As reported in the abstract
Eligible for ≥1 cardiovascular-kidney-metabolic (CKM) medication
| Group | Value | US adults represented |
|---|---|---|
| NHANES | 60% | 148 million |
| Pooled cohorts | 61% | |
| BIDMC | 42% | |
| MGB | 46% |
Observational data: associations, not effects.
Further findings
Eligible for SGLT2i
US adults represented NHANES 57.9 million
| Outcome | NHANES | Pooled cohorts | BIDMC | MGB |
|---|---|---|---|---|
| Eligible for GLP-1RA | 56% | 49% | 41% | |
| US adults represented | 137.1 million | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract |
| Eligible for nsMRA | 5% | 5% | ||
| US adults represented | 11.7 million | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract |
- Eligible for nsMRA — Ambulatory samples
- 1% to 2%
Overlapping eligibility for multiple classes
- GLP-1RA and SGLT2i
- 12% to 17%
- All 3 classes
- 1% to 5%
- All 3 classes, US adults (NHANES)
- 11.7 million
Original publication
Cardiovascular-Kidney-Metabolic Medication Eligibility Across National Survey, Community-Based, and Ambulatory Healthcare Samples. JAMA Cardiol. Published 1 March 2026. doi:10.1001/jamacardio.2025.5305
Summarised from the published abstract; every number is checked against it