Heart failure & cardiomyopathies
Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy
Authors' conclusion
Radiomic features extracted from native T1, ECV, and LGE provide incremental information that improves our capability to discriminate noncollagenous expansion from mild to moderate collagen and could be useful for detecting subtle chronic inflammation in patients with dilated cardiomyopathy.
Study context
- Population
- Patients with dilated cardiomyopathy scheduled for invasive septal biopsy who underwent CMR at 3 T
- Participants
- 132 patients
- Comparison
- CMR radiomics added to native T1, extracellular volume (ECV) and late gadolinium enhancement (LGE) vs conventional native T1 and ECV for discriminating noncollagenous from mild to moderate collagenous ECS expansion
- Low collagenn = 20
- Noncollagenous ECS expansionn = 49
- Mild to moderate collagenous ECS expansionn = 42
- Severe collagenous ECS expansionn = 21
- Outcome
- Discrimination of noncollagenous from mild to moderate collagenous ECS expansion by CMR radiomics
Methodological details3 T CMR, invasive septal biopsy reference
- 3 T CMR
- Invasive septal biopsy reference
Performance
As reported in the abstract
Net reclassification index
0.83
95% CI 0.45–1.22; P < 0.001
ECV principal radiomics · C statistic 0.79
Net reclassification index
0.93
95% CI 0.56–1.29; P < 0.001
Native T1 principal radiomics · C statistic 0.75
Net reclassification index
0.59
95% CI 0.19–0.98; P = 0.004
LGE principal radiomics · C statistic 0.74
- Native T1 alone, C statistic
- 0.59
- ECV alone, C statistic
- 0.55
Further findings
Myocardial inflammation by histopathological phenotype
- Noncollagenous expansion associated with the highest risk of myocardial inflammation
- 65%
Native T1 and ECV for differentiating severe fibrosis
- Native T1 C statistic
- 0.90
- ECV C statistic
- 0.90
Five radiomic features per sequence (correlation analysis), noncollagen vs mild to moderate collagen
- Native T1 C statistic
- 0.75
- ECV C statistic
- 0.77
- LGE C statistic
- 0.71
Single radiomic feature per sequence, noncollagen vs mild to moderate collagen
- Native T1 C statistic
- 0.71
- ECV C statistic
- 0.70
- LGE C statistic
- 0.64
- Improvements remained significant
Original publication
Summarised from the published abstract; every number is checked against it