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Heart failure & cardiomyopathiesDiagnostic or prognostic study

Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy

CirculationPublished

  • Diagnostic accuracy study
  • 3 T CMR
  • invasive septal biopsy reference
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Authors' conclusion

Radiomic features extracted from native T1, ECV, and LGE provide incremental information that improves our capability to discriminate noncollagenous expansion from mild to moderate collagen and could be useful for detecting subtle chronic inflammation in patients with dilated cardiomyopathy.

Study context

Population
Patients with dilated cardiomyopathy scheduled for invasive septal biopsy who underwent CMR at 3 T
Participants
132 patients
Comparison
CMR radiomics added to native T1, extracellular volume (ECV) and late gadolinium enhancement (LGE) vs conventional native T1 and ECV for discriminating noncollagenous from mild to moderate collagenous ECS expansion
  • Low collagenn = 20
  • Noncollagenous ECS expansionn = 49
  • Mild to moderate collagenous ECS expansionn = 42
  • Severe collagenous ECS expansionn = 21
Outcome
Discrimination of noncollagenous from mild to moderate collagenous ECS expansion by CMR radiomics

Performance

As reported in the abstract

Discrimination: noncollagen vs mild to moderate collagenous expansion
ECV principal radiomics · C statistic 0.79
net reclassification index 0.83 (95% CI 0.45–1.22); P < 0.001
Native T1 principal radiomics · C statistic 0.75
net reclassification index 0.93 (95% CI 0.56–1.29); P < 0.001
LGE principal radiomics · C statistic 0.74
net reclassification index 0.59 (95% CI 0.19–0.98); P = 0.004
Native T1 alone, C statistic
0.59
ECV alone, C statistic
0.55

Further findings

Myocardial inflammation by histopathological phenotype

Noncollagenous expansion associated with the highest risk of myocardial inflammation
65%

Native T1 and ECV for differentiating severe fibrosis

Native T1 C statistic
0.90
ECV C statistic
0.90

Five radiomic features per sequence (correlation analysis), noncollagen vs mild to moderate collagen

Native T1 C statistic
0.75
ECV C statistic
0.77
LGE C statistic
0.71

Single radiomic feature per sequence, noncollagen vs mild to moderate collagen

Native T1 C statistic
0.71
ECV C statistic
0.70
LGE C statistic
0.64
  • improvements remained significant

Original publication

Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy. Circulation. Published 29 May 2024. doi:10.1161/circulationaha.123.067107
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Summarised from the published abstract; every number is checked against it