Heart failure & cardiomyopathies
Cardiovascular magnetic resonance reveals stable myocardial tissue characteristics despite cardiac remodelling after transjugular intrahepatic portosystemic shunt in liver cirrhosis
Authors' conclusion
TIPS implantation induces progressive biventricular dilatation, increased stroke volume, and eccentric remodelling. Despite these marked structural adaptations, myocardial tissue characteristics remained largely unchanged during short- and mid-term follow-up, suggesting predominantly preload-driven cardiac remodelling.
Study context
- Population
- Patients with advanced liver cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS) implantationincluded of 45 screened, follow-up CMR-2 n = 20, CMR-3 n = 10
- Participants
- 23 patients
- Exposure
- Changes in cardiac function, remodelling, and myocardial tissue characteristics after TIPS
- CMR-2n = 20
- CMR-3n = 10
- Outcome
- Biventricular end-diastolic volumes
- Follow-up
- Baseline to final (CMR-3)
Methodological detailsmultiparametric cardiovascular magnetic resonance (CMR)
- Multiparametric CMR
Main finding
As reported in the abstract
Left ventricle (LV)
+27.2 (20.8-38.6) mL/m²
Right ventricle (RV)
+26.1 (18.2-38.0) mL/m²
Observational data: associations, not effects.
Further findings
Stroke volumes · baseline to final follow-up (CMR-3)
mL/m²
- LV
- +7.2 (3.6-15.7)
- RV
- +9.8 (2.3-15.4)
- Both P < 0.001
LV mass
g/m²
- Increased from
- 32 (30-37)
- To
- 47 (45-52)
- P < 0.001
Extracellular volume (ECV) fraction
- Remained unchanged
- 27 (23-28) % vs. 25 (23-29) %
- P = 0.06
ECV mass
g
- Increased from
- 17.1 (14.0-21.8)
- To
- 25.4 (20.7-27.4)
- P < 0.001
Native T1 or T2 values · during follow-up
- No significant changes
- all P > 0.05
Original publication
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