Cardio-oncology & otherCohort study
Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III
- Prospective observational registry study
- global
Authors' conclusion
Pregnancy outcomes in women known with Turner syndrome are better than reported before. While aortic dilatation may occur during pregnancy, it appears reversible postpartum.
Study context
- Population
- Pregnancies of women known pre-pregnancy with Turner syndrome, 2018–2023
- Participants
- 47 pregnancies
- Exposure
- Moderate-to-high vs low risk of aortic events; Assisted reproductive technology (ART) vs spontaneous conception
Main finding
As reported in the abstract
Maternal mortality or aortic dissection during or after pregnancy
- No maternal mortality or dissection occurred during or after pregnancy
Observational data: associations, not effects.
Further findings
| Outcome | Low risk | Moderate-to-high risk | Spontaneous | ART | P value |
|---|---|---|---|---|---|
| Cesarean section | Not reported in the abstract | Not reported in the abstract | 42% | 65% | P = 0.011 |
| Gestational age at delivery | Not reported in the abstract | Not reported in the abstract | 39 weeks | 38 weeks | P = 0.010 |
Aortic growth · median follow-up of seven months
- Significant aortic growth at the sinus of Valsalva during pregnancy
- Aortic diameters at follow-up not different from pre-pregnancy
Safety
Hypertensive disorders
- Hypertensive disorders
- 26%
Original publication
Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III. Eur J Prev Cardiol. Published 8 September 2025. doi:10.1093/eurjpc/zwaf574
Summarised from the published abstract; every number is checked against it