Prevention & lipidsCohort study
Cardiovascular outcomes in adults with low-density lipoprotein cholesterol levels of ≥4.9 mmol/L: 15-year follow-up of the CoLaus|PsyCoLaus study
- Prospective population-based cohort study
Authors' conclusion
The study reports an association between LDL-C ≥4.9 mmol/L and ASCVD in a large cohort from Switzerland.
Study context
- Population
- Adults without ASCVD and without lipid-lowering treatment at baseline, CoLaus|PsyCoLaus cohort (Switzerland)
- Participants
- 5,249 adults
- Exposure
- Low-density lipoprotein cholesterol (LDL-C) ≥4.9 mmol/L vs <4.9 mmol/L
- LDL-C ≥4.9 mmol/Ln = 291
- Outcome
- First-time ASCVD
- Follow-up
- Median 14.3 years
Main finding
As reported in the abstract
Adjusted hazard ratio
1.64
CI 1.10–2.44
LDL-C ≥4.9 mmol/L vs LDL-C <4.9 mmol/L
adjusted HR 1.64 (CI 1.10–2.44)
- Participants with first-time ASCVD (overall)
- 300 (3.7%)
- Of those, with LDL-C ≥4.9 mmol/L
- 27 (9%)
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (CI) | |
|---|---|---|
| First-time ASCVD, without hypertension, diabetes or smoking (subgroup, N=2497) | 1.43 (0.57–3.58) | |
| First-time ASCVD, without suspicion of familial hypercholesterolemia (subgroup, N=5101) | 1.43 (0.80–2.55) | |
| First-time ASCVD, adjusted for polygenic risk score (N=3728) | 1.46 (0.93–2.27) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Cardiovascular outcomes in adults with low-density lipoprotein cholesterol levels of ≥4.9 mmol/L: 15-year follow-up of the CoLaus|PsyCoLaus study. Eur J Prev Cardiol. Published 30 April 2025. doi:10.1093/eurjpc/zwaf268
Summarised from the published abstract; every number is checked against it