Cardio-oncology & otherMeta-analysis
Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis
- Systematic review and meta-analysis of observational studies and post hoc analyses of RCTs
- random-effects
Authors' conclusion
Breast cancer exposure was associated with the increased risk for cardiovascular death, HF, and AF. The pooled incidence for cardiovascular endpoints varied depending on population characteristics and endpoint studied.
Study context
- Population
- Breast cancer survivors142 studies
- Comparison
- Breast cancer survivors vs matched cancer-free controls
- Outcome
- CV death, HF, atrial fibrillation (AF), CAD, MI and stroke (risk and incidence rates)
Pooled result
As reported in the abstract
Risk vs matched cancer-free controls
Bc vs Matched cancer-free controlsHazard ratio (95% CI)
CV death within 5 years
1.09(1.07–1.11)
HF within 10 years
1.21(1.1–1.33)
AF within 3 years
1.13(1.05–1.21)
Further pooled results
Pooled incidence rates (IRs) of CV endpoints in breast cancer (Bc)
- CV death, pooled IR
- 1.73 (95% CI 1.18, 2.53)
- Heart failure (HF), pooled IR
- 4.44 (95% CI 3.33, 5.92)
- Coronary artery disease (CAD), pooled IR
- 4.29 (95% CI 3.09, 5.94)
- Myocardial infarction (MI), pooled IR
- 1.98 (95% CI 1.24, 3.16)
- Stroke of any type, pooled IR
- 4.33 (95% CI 2.97, 6.30)
- Ischaemic stroke, pooled IR
- 2.64 (95% CI 2.97, 6.30)
- 116 studies (2 111 882 patients) for IRs
- random-effects meta-analyses
- unit of IR not stated in the abstract
Original publication
Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 27 July 2023. doi:10.1093/eurjpc/zwad243
Summarised from the published abstract; every number is checked against it