Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population
Authors' conclusion
The higher burden of CVRFs among NHB and Hispanic survivors compared with NHW survivors was similar to the general population.
Study context
- Population
- 5-year survivors of childhood cancer diagnosed 1970–1999 (Childhood Cancer Survivor Study (CCSS)); CCSS sibling and NHANES cohorts as comparators5-year survivors
- Participants
- 24,084 survivors
- Exposure
- Non-Hispanic Black (NHB) and Hispanic vs non-Hispanic White (NHW) childhood cancer survivors
- NHBn = 1,092
- Hispanicn = 1,405
- NHWn = 13,960reference
- Outcome
- Hypertension, hyperlipidemia, diabetes, obesity and ≥2 CVRFs by race/ethnicity (IRRs)
Methodological detailslongitudinal follow-up
- Longitudinal follow-up
Main finding
As reported in the abstract
Cumulative incidence of CVRFs by 40 years of age · by 40 years of age
NHB
- Diabetes
- 8.4%
- Obesity
- 47.2%
- Multiple cardiovascular risk factors (CVRFs)
- 17.7%
- Hypertension
- 19.5%
Hispanic
- Diabetes
- 9.7%
- Obesity
- 48.9%
- Multiple CVRFs
- 16.6%
- Hypertension
- 13.6%
NHW
- Diabetes
- 5.1%
- Obesity
- 30.2%
- Multiple CVRFs
- 12.3%
- Hypertension
- 14.3%
Diabetes
NHB8.4%
Hispanic9.7%
NHW5.1%
Obesity
NHB47.2%
Hispanic48.9%
NHW30.2%
Multiple cardiovascular risk factors (CVRFs)
NHB17.7%
Hispanic16.6%
NHW12.3%
Hypertension
NHB19.5%
Hispanic13.6%
NHW14.3%
Each group vs NHWIncidence rate ratio (95% CI)
NHBhypertension
1.4(1.1–1.8)
NHBobesity
1.7(1.4–2.1)
NHBmultiple CVRFs
1.6(1.2–2.1)
Hispanicdiabetes
1.8(1.2–2.6)
Hispanicobesity
1.4(1.2–1.7)
Observational data: associations, not effects.
Further findings
CVRF disparities in CCSS sibling and NHANES cohorts
- Pattern of incidence rate ratios (IRRs) for CVRF differences similar among CCSS sibling and NHANES cohorts
Original publication
Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population. JACC CardioOncol. Published 11 April 2023. doi:10.
Summarised from the published abstract; every number is checked against it