Cardio-oncology & otherCohort study
Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population
- Retrospective cohort study
- longitudinal follow-up
Authors' conclusion
The higher burden of CVRFs among NHB and Hispanic survivors compared with NHW survivors was similar to the general population.
Study context
- Population
- 5-year survivors of childhood cancer diagnosed 1970–1999 (Childhood Cancer Survivor Study (CCSS)); CCSS sibling and NHANES cohorts as comparators5-year survivors
- Participants
- 24,084 survivors
- Exposure
- Non-Hispanic Black (NHB) and Hispanic vs non-Hispanic White (NHW) childhood cancer survivors
- NHBn = 1,092
- Hispanicn = 1,405
- NHWn = 13,960reference
- Outcome
- Hypertension, hyperlipidemia, diabetes, obesity and ≥2 CVRFs by race/ethnicity (IRRs)
Main finding
As reported in the abstract
Cumulative incidence of CVRFs by 40 years of age · by 40 years of age
NHB
8.4%
Diabetes · Obesity 47.2% · Multiple Cardiovascular Risk Factors (CVRFs) 17.7% · Hypertension 19.5%
Hispanic
9.7%
Diabetes · Obesity 48.9% · Multiple CVRFs 16.6% · Hypertension 13.6%
NHW
5.1%
Diabetes · Obesity 30.2% · Multiple CVRFs 12.3% · Hypertension 14.3%
Each group vs NHWIncidence rate ratio (95% CI)
NHBhypertension
1.4(1.1–1.8)
NHBobesity
1.7(1.4–2.1)
NHBmultiple CVRFs
1.6(1.2–2.1)
Hispanicdiabetes
1.8(1.2–2.6)
Hispanicobesity
1.4(1.2–1.7)
Observational data: associations, not effects.
Further findings
CVRF disparities in CCSS sibling and NHANES cohorts
- Pattern of incidence rate ratios (IRRs) for CVRF differences similar among CCSS sibling and NHANES cohorts
Original publication
Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population. JACC CardioOncol. Published 11 April 2023. doi:10.1016/j.jaccao.2023.01.011
Summarised from the published abstract; every number is checked against it