Prevention & lipidsCohort study
Cardiovascular risk in inflamed Danish women and men without standard modifiable risk factors
- Prospective cohort study
Authors' conclusion
Elevated hsCRP levels are associated with increased risk of future cardiovascular disease in low-risk Danish women and men.
Study context
- Population
- SMuRF-less and SCORE2/SCORE2-OP/PREVENT low-risk individuals aged 20–100 years without CVD, Copenhagen General Population Study21,085 SMuRF-less
- Exposure
- Highest vs lowest hsCRP category
- Outcome
- MACE
- Follow-up
- Median 11.4 years
Main finding
As reported in the abstract
MACE, multivariable adjusted
Hazard ratio (95% CI)
hsCRP ≥3 mg/L vs hsCRP <1 mg/LSMuRF-less
1.35(1.08–1.68)
hsCRP ≥1.5 mg/L vs hsCRP <0.9 mg/LSMuRF-less
1.36(1.14–1.62)
hsCRP ≥3 mg/L vs hsCRP <1 mg/LSCORE2/SCORE2-OP low-risk
1.47(1.27–1.71)
hsCRP ≥1.5 mg/L vs hsCRP <0.9 mg/LSCORE2/SCORE2-OP low-risk
1.39(1.24–1.57)
hsCRP ≥3 mg/L vs hsCRP <1 mg/LPREVENT low-risk
1.36(1.20–1.55)
hsCRP ≥1.5 mg/L vs hsCRP <0.9 mg/LPREVENT low-risk
1.33(1.20–1.47)
Observational data: associations, not effects.
Further findings
CHD and ischaemic stroke, cumulative incidence
- Cumulative incidence of major adverse cardiovascular events (MACE) and CHD increased across hsCRP thresholds and tertiles in all populations
- Ischaemic stroke only slightly higher with elevated hsCRP
Original publication
Cardiovascular risk in inflamed Danish women and men without standard modifiable risk factors. Eur J Prev Cardiol. Published 10 July 2026. doi:10.1093/eurjpc/zwag349
Summarised from the published abstract; every number is checked against it