Cardiovascular Risk Stratification by Automatic Coronary Artery Calcium Scoring on Pretreatment Chest Computed Tomography in Diffuse Large B-Cell Lymphoma Receiving Anthracycline-Based Chemotherapy: A Multicenter Study
Authors' conclusion
The automatic CACS derived from chest computed tomography before treatment was helpful to identify high-risk patients of CTRCD and MACE
Study context
- Population
- Patients with diffuse large B-cell lymphoma receiving anthracycline-based chemotherapy, 4 hospitals
- Participants
- 1,468 patients4 hospitals
- Exposure
- CAC score 1-100 and >100 vs 0 on pretreatment chest CT
- Coronary artery calcium score (CACS) 0n = 826reference
- CACS 1-100n = 356
- CACS >100n = 286
- Outcome
- Cancer therapy-related cardiac dysfunction (CTRCD) and MACE
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- CACS 1-100 · cancer therapy-related cardiac dysfunction (CTRCD)
- OR 2.587
- CACS >100 · CTRCD
- OR 5.239
- CACS 1-100 · MACE
- subdistribution HR 3.726; P < 0.001
- CACS >100 · MACE
- subdistribution HR 7.858; P < 0.001
- Patients developing CTRCD
- 362
- Patients developing MACE
- 185
Observational data: associations, not effects.
Further findings
Competing risk-adjusted MACE rates · 3 years
Competing risk-adjusted MACE rates · 5 years
Original publication
Cardiovascular Risk Stratification by Automatic Coronary Artery Calcium Scoring on Pretreatment Chest Computed Tomography in Diffuse Large B-Cell Lymphoma Receiving Anthracycline-Based Chemotherapy: A Multicenter Study. Circ Cardiovasc Imaging. Published 7 February 2023. doi:10.
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