Heart failure & cardiomyopathies
Cardiac shockwave therapy in addition to coronary bypass surgery improves myocardial function in ischaemic heart failure: the CAST-HF trial
Authors' conclusion
In conclusion, the CAST-HF trial indicates that direct cardiac SWT, in addition to coronary bypass surgery improves LVEF and physical capacity in patients with ischaemic heart failure.
Study context
- Population
- Patients with ischaemic HF, left ventricular ejection fraction (LVEF) ≤40%, requiring surgical revascularisation30 shockwave therapy (SWT), 28 Sham at 1-year follow-up
- Participants
- 63 patients
- Comparison
- Cardiac SWT vs sham, in addition to CABG
- Primary endpoint
- Improvement in LVEF by CMR from baseline
- Follow-up
- 360 days
Methodological detailssingle-blind, parallel-group, sham-controlled
- Single-blind
- Parallel-group
- Sham-controlled
Primary result
As reported in the abstract
Change in LVEF · baseline to 360 days
SWT
11.3%
SD 8.8
Sham
6.3%
SD 7.4
P = 0.0146
Secondary outcomes
6-minute walking test · baseline to 360 days
P = 0.028
Minnesota Living with Heart Failure Questionnaire score · day 360
P = 0.15
Original publication
Cardiac shockwave therapy in addition to coronary bypass surgery improves myocardial function in ischaemic heart failure: the CAST-HF trial. Eur Heart J. Published 20 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it