Aortic & peripheral vascular diseaseCohort study
Categorization of patients with peripheral artery disease by Charlson Comorbidity Index
- Retrospective cohort study
- nationwide
- German inpatient statistics
Authors' conclusion
Higher comorbidity burden mirrored by higher CCI class was associated with an approximately 10-fold increased risk for MACCE and in-hospital mortality.
Study context
- Population
- Hospitalizations of patients admitted due to peripheral artery disease (PAD) in Germany 2005–2022
- Participants
- 3,167,987 hospitalizations
- Exposure
- Charlson Comorbidity Index (CCI) classes
Main finding
As reported in the abstract
Outcomes per increase in CCI class · in-hospital
Increase in CCI classOdds ratio (95% CI)P value
MACCE
9.66(9.45–9.88)
P < 0.001amputation
2.82(2.80–2.84)
P < 0.001in-hospital case-fatality
9.87(9.62–10.12)
P < 0.001Per increase in CCI class, as printed
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Treatment type per increase in CCI class — Increase in CCI class · endovascular treatment | 1.48 (1.48–1.49) | P < 0.001 | |
| Treatment type per increase in CCI class — Increase in CCI class · surgical treatment | 0.87 (0.87–0.88) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
High-severity CCI class frequency over time
- Increased from 2006 to 2022
- 51.2% (2006) to 58.5% (2022)
Original publication
Categorization of patients with peripheral artery disease by Charlson Comorbidity Index. Eur J Prev Cardiol. Published 10 March 2026. doi:10.1093/eurjpc/zwag146
Summarised from the published abstract; every number is checked against it