Catheter ablation as an adjunctive therapy to ICD implantation in Brugada Syndrome

Doundoulakis, I; Chiotis, S; Pannone, L; Della Rocca, DG; Sorgente, A; Kordalis, A; Scacciavillani, R; Zafeiropoulos, S; Marcon, L; Vetta, G; Pagkalidou, E; Bala, G; Almorad, A; Ströker, E; Sieira, J; La Meir, M; Brugada, P; Tsiachris, D; Sarkozy, A; Chierchia, GB; de Asmundis, C

doi:10.1093/ehjqcco/qcae040

Catheter ablation as an adjunctive therapy to ICD implantation in Brugada Syndrome

Eur Heart J Qual Care Clin OutcomesPublished 22 May 2024Systematic review and meta-analysis

Pooled result · VAs during follow-up (freedom from VAs after CA; incidence of VAs, CA vs ICD only)ResultOdds ratio 0.03 95% CI 0.01–0.12

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Authors' conclusion

CA shows potential as a therapeutic approach to reduce VAs and improve outcomes in BrS patients.

Study context

Population: Brugada Syndrome patients undergoing catheter ablation (CA) for ventricular arrhythmias
Participants: 709 patients14 studies

Comparison: Catheter ablation vs ICD therapy only
CAn = 528
Outcome: VAs during follow-up (freedom from VAs after CA; incidence of VAs, CA vs ICD only)
Follow-up: Mean 30.7 months

Pooled result

As reported in the abstract

Odds ratio

0.03

95% CI 0.01–0.12

CAvs ICD only

OR 0.03 (95% CI 0.01–0.12)

Free from ventricular arrhythmias (VAs) after CA: 87% (95% CI: 80-94, I2 = 82%)

Original publication

Catheter ablation as an adjunctive therapy to ICD implantation in Brugada Syndrome. Eur Heart J Qual Care Clin Outcomes. Published 22 May 2024. doi:10.1093/ehjqcco/qcae040

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