Meta-analysis
Catheter ablation of atrial fibrillation in patients with and without hypertrophic cardiomyopathy: systematic review and meta-analysis
- Systematic review and meta-analysis of cohort studies
- random-effects meta-analysis
Authors' conclusion
Compared to non-HCM patients, those with HCM had higher rates of recurrent atrial arrhythmias, AAD use, and need for repeat AF ablation after initial ablation of AF.
Study context
- Population
- Patients undergoing atrial fibrillation (AF) catheter ablation, with vs without hypertrophic cardiomyopathy8 studies
- Participants
- 262 vs 642
- Comparison
- AF catheter ablation in hypertrophic cardiomyopathy (HCM) vs non-HCM
- HCMn = 262
- non-HCMn = 642reference
- Outcome
- Recurrent atrial arrhythmia after the first AF ablation
Pooled result
As reported in the abstract
Recurrent atrial arrhythmia after first AF ablation
Relative risk
1.498
95% CI 1.305–1.720
P < 0.001
HCM vs non-HCM
RR 1.498 (95% CI 1.305–1.720); P < 0.001
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| AAD therapy required | 2.844 (1.713–4.856) | P < 0.001 | |
| Repeat AF ablation | 1.544 (1.070–2.228) | P = 0.02 | |
| Recurrent atrial arrhythmias after last AF ablation | 1.607 (1.235–2.090) | P < 0.001 | |
| 0.20.5125Relative risk (log scale) |
| Outcome | HCM | non-HCM | Estimate | P value |
|---|---|---|---|---|
| AF recurrence rates across studies · median follow-up 13-54 months · range across studies | 13.3% to 92.9% | 7.6% to 58.8% |
Original publication
Catheter ablation of atrial fibrillation in patients with and without hypertrophic cardiomyopathy: systematic review and meta-analysis. Europace. Published 18 August 2023. doi:10.1093/europace/euad256
Summarised from the published abstract; every number is checked against it