Arrhythmias & electrophysiology
Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes
An erratum to this article was published (Europace, 4 Aug 2025 ↗)
Authors' conclusion
Patients with infiltrative cardiomyopathies exhibit higher rates of non-PV triggers and left AFLs during first-time AF ablation. Those with cardiac amyloidosis experience higher arrhythmia recurrence rates compared with controls.
Study context
- Population
- Patients with cardiac amyloidosis or cardiac sarcoidosis undergoing first-time atrial fibrillation (AF) ablation
- Participants
- 24 / 96 / 17 / 68
- Exposure
- AF ablation in cardiac amyloidosis or cardiac sarcoidosis vs matched controls
- Cardiac amyloidosisn = 24
- Amyloidosis controlsn = 96reference
- Cardiac sarcoidosisn = 17
- Sarcoidosis controlsn = 68reference
- Outcome
- Procedural findings: non-PV triggers and macro-reentrant atrial flutters
Methodological details1:4 matching
- 1:4 matching
Main finding
As reported in the abstract
Non-PV triggers
Cardiac amyloidosis vs Amyloidosis controls
Estimate (95% CI)
Odds ratio
4.5(1.4–14.2)
Cardiac sarcoidosis vs Sarcoidosis controls
Estimate (95% CI)
Odds ratio
2.7(0.6–12.6)
Observational data: associations, not effects.
Further findings
| Outcome | Cardiac amyloidosis | Amyloidosis controls | Cardiac sarcoidosis | Sarcoidosis controls | OR (95% CI) | |
|---|---|---|---|---|---|---|
| Left atrial macro-reentrant flutters (amyloidosis)Cardiac amyloidosisvs Amyloidosis controls | 37.5% | 6.3% | — not stated in the abstract | — not stated in the abstract | 9.0 (2.8–29.0) | |
| 0.050.21520Odds ratio (log scale) |
— not stated in the abstract
Recurrence (AF/AT/AFL ≥ 30 s after 90-day blanking) · 1 year — Cardiac sarcoidosis vs Sarcoidosis controls
P = 0.965
| Outcome | P value |
|---|---|
| Recurrence (AF/AT/AFL ≥ 30 s after 90-day blanking) · 1 yearCardiac amyloidosis vs Amyloidosis controls | P = 0.049 |
Original publication
Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes. Europace. Published 20 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →