Arrhythmias & electrophysiologyCohort study
Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes
- Propensity-score matched cohort study
- 1:4 matching
Authors' conclusion
Patients with infiltrative cardiomyopathies exhibit higher rates of non-PV triggers and left AFLs during first-time AF ablation. Those with cardiac amyloidosis experience higher arrhythmia recurrence rates compared with controls.
Study context
- Population
- Patients with cardiac amyloidosis or cardiac sarcoidosis undergoing first-time atrial fibrillation (AF) ablation
- Participants
- 24 / 96 / 17 / 68
- Exposure
- AF ablation in cardiac amyloidosis or cardiac sarcoidosis vs matched controls
- Cardiac amyloidosisn = 24
- Amyloidosis controlsn = 96reference
- Cardiac sarcoidosisn = 17
- Sarcoidosis controlsn = 68reference
- Outcome
- Procedural findings: non-PV triggers and macro-reentrant atrial flutters
Main finding
As reported in the abstract
Non-PV triggers
Odds ratio (95% CI)
Cardiac amyloidosis vs Amyloidosis controls
4.5(1.4–14.2)
Cardiac sarcoidosis vs Sarcoidosis controls
2.7(0.6–12.6)
Observational data: associations, not effects.
Further findings
| Outcome | Cardiac amyloidosis | Amyloidosis controls | Cardiac sarcoidosis | Sarcoidosis controls | OR (95% CI) | P value | |
|---|---|---|---|---|---|---|---|
| Left atrial macro-reentrant flutters (amyloidosis) | 37.5% | 6.3% | Not reported in the abstract | Not reported in the abstract | 9.0 (2.8–29.0) | ||
| 0.050.21520Odds ratio (log scale) |
Recurrence (AF/AT/AFL ≥ 30 s after 90-day blanking) · 1 year — Cardiac sarcoidosis vs Sarcoidosis controls
P = 0.965
| Outcome | Estimate | P value |
|---|---|---|
| Recurrence (AF/AT/AFL ≥ 30 s after 90-day blanking) · 1 year — Cardiac amyloidosis vs Amyloidosis controls | P = 0.049 |
Original publication
Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes. Europace. Published 20 June 2025. doi:10.1093/europace/euaf100
Summarised from the published abstract; every number is checked against it