Heart failure & cardiomyopathies
Catheter ablation vs advanced therapy for patients with severe heart failure and ventricular electrical storm
Authors' conclusion
Patients with severe HF and ES who underwent VT ablation had similar overall survival to patients who directly proceeded with advanced therapy, although rates of HT were high during follow-up.
Study context
- Population
- Patients with severe heart failure (HF) (EF ≤ 35% or severe restrictive, valvular or genetic cardiomyopathy) and ventricular electrical storm, 2012–2022
- Participants
- 73 patients
- Exposure
- Ventricular tachycardia (VT) ablation vs advanced therapy
- VT ablationn = 43
- Advanced therapyn = 30reference
- Outcome
- In-hospital adverse events and 1-year outcomes
- Follow-up
- 1 year
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
One-year survival
- One-year survival similar, VT ablation vs advanced therapy (76.7% vs 86.7%; log-rank)
- P = .308
Observational data: associations, not effects.
Further findings
Predictors of heart transplantation (HT) or mortality after VT ablation (multivariable)
| HR (95% CI) | P value | ||
|---|---|---|---|
| United Network for Organ Sharing status 1 or 2 by VT criteriaMultivariable analysis | 5.52 (1.27–24.12) | P = 0.023 | |
| Early VT recurrenceMultivariable analysis | 5.67 (1.68–19.09) | P = 0.005 | |
| 0.050.21520Hazard ratio (log scale) |
HT during follow-up after VT ablation
- Patients in the ablation group who underwent HT during follow-up: 10 (23.3%)
Original publication
Catheter ablation vs advanced therapy for patients with severe heart failure and ventricular electrical storm. Heart Rhythm. Published 26 September 2024. doi:10.
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