Arrhythmias & electrophysiology
Catheter-based left atrial appendage CLOSURE in patients with atrial fibrillation at high risk of stroke and bleeding as compared to best medical therapy: Rationale and design of the prospective randomized CLOSURE-AF trial
Study context
- Population
- Patients with atrial fibrillation (AF) at high risk of stroke and with either a history of bleeding or a high estimated bleeding risk (HASBLED ≥ 3)complete study cohort enrolled by April 2025 in 42 sites
- Participants
- 912 patients
- Planned comparison
- Catheter-based left atrial appendage (LAA) closure to best medical care
- Primary endpoint
- time to a composite of:
- First stroke (ischemic or hemorrhagic)
- Systemic embolism
- Cardiovascular or unexplained death or major bleeding (Bleeding Academic Research Consortium 3-5)
Methodological detailsrationale and design
- Rationale and design
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Enrollment · March 2018 to April 2025
- First patient enrolled
- March 2018
- Complete study cohort enrolled by April 2025
- n = 912
- Sites
- 42
Original publication
Catheter-based left atrial appendage CLOSURE in patients with atrial fibrillation at high risk of stroke and bleeding as compared to best medical therapy: Rationale and design of the prospective randomized CLOSURE-AF trial. Am Heart J. Published 12 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →