Arrhythmias & electrophysiology
Causal mitochondrial signatures in atrial fibrillation: Insights from integrated multi-omics and multi-faceted approaches
Authors' conclusion
The study identified 16 mitochondrial genes associated with AF and demonstrated the potential of mitochondrial genes as biomarkers.
Study context
- Population
- Mitochondrial genes from MitoCarta version 3.0 and atrial fibrillation (AF) (from FinnGen)
- Comparison
- Mitochondrial gene methylation, expression and protein QTLs as instrumental variables vs risk of AF
- Outcome
- Mitochondrial genes identified via MR and SMR analyses
Methodological detailsintegrated multi-omics, Benjamini-Hochberg method employed to control for false positives, single-cell RNA sequencing, predictive models
- Integrated multi-omics
- Benjamini-Hochberg method employed to control for false positives
- Single-cell RNA sequencing
- Predictive models
Main finding
As reported in the abstract
Genes identified via MR and SMR analyses
16
Further findings
NME4 gene and AF
- NME4 demonstrated consistent causal associations with AF across all 3 levels; methylation at cg08183303, high gene expression and elevated protein levels associated with an increased risk of AF
Cellular-level expression of key gene
- Key gene highly expressed in fibroblasts, with expression levels dynamically changing as cells evolve
Machine learning prediction models
- Good performance in disease prediction
Original publication
Causal mitochondrial signatures in atrial fibrillation: Insights from integrated multi-omics and multi-faceted approaches. Heart Rhythm. Published 2 July 2026. doi:10.
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