Acute cardiac care & resuscitationResearch article
Cerebral tissue oxygen saturation at defibrillation and return of spontaneous circulation in out-of-hospital cardiac arrest with a shockable rhythm
- Multivariable Firth penalized logistic regression analysis of first monitored defibrillation
- logistic generalized linear mixed-effects model (GLMM) with a patient-level random intercept (secondary)
- adjusted for site
Authors' conclusion
In this selected population, higher SctO2 at defibrillation was associated with ROSC. This indirect marker and exploratory cutoff need external validation and should not delay guideline-directed defibrillation.
Study context
- Population
- Adult patients with out-of-hospital cardiac arrest who underwent SctO2 monitoring during ongoing CPR and received in-hospital defibrillation for ventricular fibrillation or pulseless ventricular tachycardia
- Comparison
- SctO2 at first monitored defibrillation and return of spontaneous circulation (ROSC) after that defibrillation
- ROSCn = Nineteen
Main finding
As reported in the abstract
SctO2 at first monitored defibrillation
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| ROSC after first monitored defibrillation, per 1% increase in SctO2 | 1.48 (1.22–1.80) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
ROSC across all 194 monitored defibrillations (41 followed by ROSC), adjusted GLMM
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| SctO2 · association remained consistent | 1.56 (1.34–1.82) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
- ROSC after first monitored defibrillation, per 1% increase in SctO2: adjusted for site, arrest-to-defibrillation time, and epinephrine within 2 min
Discrimination of SctO2 for ROSC
- Area under the receiver operating characteristic curve
- 0.961 (95% CI, 0.917-0.991)
- Sensitivity at SctO2 cut-off of 44.5%
- 94.7% (18/19; 95% CI, 74.0%-99.9%)
- Specificity at SctO2 cut-off of 44.5%
- 89.7% (61/68; 95% CI, 79.9%-95.8%)
Original publication
Cerebral tissue oxygen saturation at defibrillation and return of spontaneous circulation in out-of-hospital cardiac arrest with a shockable rhythm. Resuscitation. Published 31 August 2026. doi:10.1016/j.resuscitation.2026.111286
Summarised from the published abstract; every number is checked against it