Valvular & structural heart disease
Changes in Demographics, Initial Treatment Strategies, and Clinical Outcomes of Severe Aortic Stenosis in the Pre- and Post-TAVR Era in Japan
Main finding · All-cause mortalityResult — go to the resultHazard ratio 0.55 95% CI 0.47–0.63Authors' conclusion
The overall 1-year mortality outcome of patients with severe aortic stenosis improved in the posttranscatheter AVR era compared with the pretranscatheter AVR era, with no noticeable improvement in hospitalization for heart failure.
Study context
- Population
- Patients with severe aortic stenosis before and after the introduction of transcatheter aortic valve replacement (AVR) in Japanpatients included
- Participants
- 6,645 patients
- Exposure
- Registry-2 vs Registry-1
- Registry-2n = 3,197
- Registry-1n = 3,448reference
- Outcome
- All-cause mortality
- Follow-up
- 1 year
Methodological detailsconsecutively enrolled, Data were derived from hospital electronic health records, Multivariable Cox proportional hazards models
- Consecutively enrolled
- Data were derived from hospital electronic health records
- Multivariable Cox proportional hazards models
Main finding
As reported in the abstract
Hazard ratio
0.55
95% CI 0.47–0.63
P < 0.001
By group
Registry-2vs Registry-1
hazard ratio 0.55 (95% CI 0.47–0.63); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
Age
Initial AVR strategy
Incidence
| Outcome | Registry-2 | Registry-1 | Hazard ratio (95% CI) | P value | |
|---|---|---|---|---|---|
| Hospitalization for heart failureAdjusted | 8.5% | 9.0% | 0.88 (0.75–1.04) | P = 0.66 | |
| 0.512Hazard ratio (log scale) |
Original publication
Changes in Demographics, Initial Treatment Strategies, and Clinical Outcomes of Severe Aortic Stenosis in the Pre- and Post-TAVR Era in Japan. Circ Popul Health Outcomes. Published 23 January 2026. doi:10.
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