Valvular & structural heart diseaseResearch article
Changes in Biventricular Cardiac Mechanics After Transcatheter Edge-to-Edge Repair for Severe Tricuspid Regurgitation
- Pre- and postprocedural invasive pressure-volume analysis
- conductance catheter
- paired-samples t-test or Wilcoxon signed rank test
Authors' conclusion
TR reduction with tricuspid TEER generated immediate RV volume unloading, increased RV afterload, and enhanced RV contractility, maintaining forward stroke volume and increasing LV preload.
Study context
- Population
- Patients with severe tricuspid regurgitation undergoing tricuspid transcatheter edge-to-edge repair (TEER)patients with severe tricuspid regurgitation (TR)
- Participants
- twenty-two patients
- Comparison
- Pre- and postprocedural changes in cardiac mechanics
Main finding
As reported in the abstract
TR
- significant TR reduction
Further findings
RV end-diastolic volume
LV end-diastolic volume
RV afterload (Ea)
RV contractility (Ees)
- RV end-diastolic volume: P < 0.001
- RV afterload (elastance (Ea)): P < 0.001
- RV contractility (Ees): P < 0.001
- LV end-diastolic volume: P < 0.001
RV Ees/Ea, stroke volume, RV end-diastolic pressure, PV area (PVA), stroke work-to-PVA ratio
- stable RV Ees/Ea, preserved stroke volume, RV end-diastolic pressure, PVA, and stroke work-to-PVA ratio
LV pressures, contractility, Ees/Ea, PVA, stroke work-to-PVA
- remained unchanged
Original publication
Changes in Biventricular Cardiac Mechanics After Transcatheter Edge-to-Edge Repair for Severe Tricuspid Regurgitation. JACC Adv. Published 21 January 2026. doi:10.1016/j.jacadv.2025.102549
Summarised from the published abstract; every number is checked against it