Heart failure & cardiomyopathiesSecondary analysis
Changes in Cardiac Structure and Function are Associated with Health-Related Quality of Life in Heart Failure Patients with Reduced Ejection Fraction: Results from the EVALUATE-HF trial
- Secondary analysis of the EVALUATE-HF randomised trial
Authors' conclusion
In the EVALUATE-HF trial, increases in mitral e' velocities and decreases in septal E/e' ratio and LAVi were associated with improved KCCQ-12 scores over 24 weeks, after adjusting for treatment assignment.
Study context
- Population
- Heart failure with reduced ejection fraction (HFrEF) patients randomised to sacubitril-valsartan or enalapril for 12 weeks, then 12 weeks open-label sacubitril-valsartan
- Participants
- 406 patients
- Comparison
- Changes in echocardiographic measures vs changes in KCCQ-12 scores
- Primary endpoint
- Association of changes in echocardiographic measures with changes in KCCQ-12-OSS
- Follow-up
- 24 weeks
Primary result
As reported in the abstract
KCCQ-12-OSS change per SD change in echo measure
Septal e' velocity, per SD increase
+2.5 points
Lateral e' velocity, per SD increase
+2.3 points
Septal E/e' ratio, per SD decrease
+3.2 points
Left atrial volume index (LAVi), per SD decrease
+2.0 points
Further findings
KCCQ-12-OSS change (all patients) · 24 weeks
- KCCQ-12-OSS improvement
- +9 points (95% CI +7 to +11 points)
Other KCCQ-12 domains
- Similar associations observed
Original publication
Changes in Cardiac Structure and Function are Associated with Health-Related Quality of Life in Heart Failure Patients with Reduced Ejection Fraction: Results from the EVALUATE-HF trial. Eur J Heart Fail. Published 18 July 2025. doi:10.1002/ejhf.3760
Summarised from the published abstract; every number is checked against it