Cohort study
Changes in Pulmonary Artery Pressure Late in Life
- Prospective cohort study
- community-based cohort (ARIC)
Authors' conclusion
Pulmonary pressure increased over 6.5 years in late life, was associated with concomitant increases in LV filling pressure, and predicted the development of dyspnea.
Study context
- Population
- Older adults in the ARIC study with echocardiographic pulmonary artery systolic pressure (PASP) at visits 5 (2011–2013) and 7 (2018–2019)
- Participants
- 1,420 adults
- Outcome
- Change in PASP and contributions of cardiac and pulmonary dysfunction
- Follow-up
- About 6.5 years
Main finding
As reported in the abstract
Change in PASP · 6.5 years
PASP increase (mean ± SD)
5 ± 8 mm Hg
PASP from visit 5 to visit 7
28 ± 5 to 33 ± 8 mm Hg
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Developing dyspnea · 16% higher odds | 1.16 (1.07–1.27) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
PASP change by age
- PASP increased more in older participants
Predictors of greater PASP increase
- Worse left ventricular (LV) systolic and diastolic function, pulmonary function and renal function
LV filling pressure (E/e' ratio, left atrial volume index)
- PASP increases associated with concomitant increases in LV filling pressure measures
Original publication
Changes in Pulmonary Artery Pressure Late in Life. J Am Coll Cardiol. Published 5 December 2023. doi:10.1016/j.jacc.2023.09.821
Summarised from the published abstract; every number is checked against it