Valvular & structural heart diseaseCohort study
Changes in Right Ventricular Function and Clinical Outcomes Following Tricuspid Transcatheter Edge-to-Edge Repair
- Retrospective cohort study
Authors' conclusion
Post-procedural increase in RVFAC after T-TEER is associated with improved outcomes in patients with RV dysfunction.
Study context
- Population
- Patients undergoing tricuspid transcatheter edge-to-edge repair (T-TEER) with echocardiographic follow-up at 3 months45 with baseline RV fractional area change (RVFAC) <35%
- Participants
- 204 patients
- Exposure
- Right ventricular (RV) responders vs RV non-responders after T-TEER, by baseline RVFAC
- RV respondersn = 71
- Outcome
- Composite of:
- Mortality
- HF hospitalization
- Follow-up
- Within 1 year
Main finding
As reported in the abstract
- Baseline RVFAC <35%: RV responders had a lower risk of the composite outcome than RV non-responders
- Baseline RVFAC ≥35%: association not significant
- Significant interaction between RV responder and baseline RVFAC
Observational data: associations, not effects.
Further findings
Predictors of RV response (baseline RVFAC <35%)
- Smaller RV diameter and greater reduction of tricuspid regurgitation predicted RV response
Original publication
Changes in Right Ventricular Function and Clinical Outcomes Following Tricuspid Transcatheter Edge-to-Edge Repair. Eur J Heart Fail. Published 7 March 2024. doi:10.1002/ejhf.3183
Summarised from the published abstract; every number is checked against it