Heart failure & cardiomyopathiesCohort study
Characteristics and Outcomes of Patients with Heart Failure and History of Malignancy: Data from Swedish Heart Failure Registry and the National Cancer Register
- Registry-based cohort study
- Swedish heart failure (HF) Registry linked with National Cancer Register
Authors' conclusion
Previous cancer was common among patients with HF, and it was associated with comorbidity burden, non-cardiovascular outcomes and, in HFrEF, with lower use of guideline-recommended therapies.
Study context
- Population
- Patients with HF in the Swedish HF Registry, 2000–2020
- Participants
- 53,314 patients
- Exposure
- Previous cancer vs no previous cancer
- Previous cancern = 9,066
Main finding
All-cause mortality · median follow-up 2.4 (0.0-5.0) years
Adjusted hazard ratio
1.14
95% CI 1.11–1.18
By group
Previous cancer vs No cancer
adjusted HR 1.14 (95% CI 1.11–1.18)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | |
|---|---|---|
| Non-CV death | 1.38 (1.31–1.44) | |
| First all-cause hospitalization | 1.11 (1.09–1.14) | |
| 0.512Adjusted hazard ratio (log scale) |
Deaths due to cancer
Non-CV death
- Risk of non-CV death declined with increasing time from cancer diagnosis
HF therapy use in HF and reduced ejection fraction (HFrEF)
- Previous cancer associated with less frequent use of MRA, triple pharmacotherapy and HF devices
Original publication
Characteristics and Outcomes of Patients with Heart Failure and History of Malignancy: Data from Swedish Heart Failure Registry and the National Cancer Register. Eur J Heart Fail. Published 17 July 2025. doi:10.1002/ejhf.3775
Summarised from the published abstract; every number is checked against it