Arrhythmias & electrophysiology
Characteristics of patients with Brugada syndrome and monomorphic ventricular tachycardia
Authors' conclusion
VF/PVT and MVT in patients with BrS have distinct clinical presentations. MVT shows a later onset compared with VF/PVT and is associated with a broader substrate area.
Study context
- Population
- Patients with brugada syndrome (BrS) who received an implantable cardioverter-defibrillator (ICD), with initiation of ventricular arrhythmia on ICD recordings and no antiarrhythmic drugs or previous ventricular ablationmet the inclusion criteria, among 793 patients with BrS with ICDs (44.2 ± 17.7 years, 37.1% women)
- Participants
- 54 patients
- Exposure
- Patients with BrS presenting with MVT compared with those with ventricular fibrillation (VF)
- Outcome
- Arrhythmic episodes on ICD recordings
Main finding
As reported in the abstract
VF
47
events
MVT
27
events
Observational data: associations, not effects.
Further findings
Age at first event · older with MVT
P = 0.06
Time to recurrence after ICD implantation · later recurrences with MVT
P = 0.018
Rapid rhythms (>100 beats/min) before arrhythmia · more frequent before MVT
P < 0.001
Abnormal epicardial substrate area in baseline conditions · broader with MVT
P = 0.006
| Outcome | MVT | VF | P value |
|---|---|---|---|
| Ectopy before arrhythmiaLower incidence before MVT | 22.2% | 61.7 | P = 0.001 |
QRS duration and syncope
- Patients with MVT had higher QRS duration, more prevalence of syncope
Original publication
Characteristics of patients with Brugada syndrome and monomorphic ventricular tachycardia. Heart Rhythm. Published 20 June 2025. doi:10.
Summarised from the published abstract; every number is checked against it