Heart failure & cardiomyopathiesCohort study
Characterization of incident heart failure after ischaemic stroke/transient ischaemic attack: a UK Biobank study
- prospective cohort study
Authors' conclusion
Incident HF is common in stroke survivors and strongly associates with mortality. The risk of HF varies greatly depending on underlying risk factors. Exploratory analyses suggest that stroke survivors with HF may have a lower ejection fraction phenotype. Future trials of HF preventive therapy in high-risk stroke survivors are warranted.
Study context
- Population
- Individuals aged 40 to 69 years old in the UK Biobank (UKBB) cohort without prior heart failure (HF), stratified by history of ischaemic stroke/TIAage 56.5 years, 45.6% males
- Participants
- 405,406 individuals
- Exposure
- Individuals with vs without history of ischaemic stroke/TIA
- Outcome
- Incident HF (hospital admissions coded for heart failure)
- Follow-up
- Over 13.7 years
Main finding
As reported in the abstract
Stroke survivors vs No history of ischaemic stroke/TIAHazard ratio (95% CI)P value
overall
3.6(3.3–3.8)
P < 0.0001adjusted
1.4(1.3–1.5)
P < 0.0001- Individuals with incident HF
- 15 565
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality associated with incident HF in stroke survivors | 1.8 (1.6–1.9) | P < 0.0001 | |
| 0.512Hazard ratio (log scale) |
Risk of HF hospitalization vs myocardial infarction
- HF hospitalization
- 12.6%
- Myocardial infarction
- 5.4%
Cardiac magnetic resonance (CMR) findings in stroke survivors with vs without HF
- Stroke survivors with HF had a lower LVEF and higher LV mass than those without HF
Original publication
Characterization of incident heart failure after ischaemic stroke/transient ischaemic attack: a UK Biobank study. ESC Heart Fail. Published 13 May 2026. doi:10.1093/eschf/xvag123
Summarised from the published abstract; every number is checked against it