Cohort study
Characterization of Screen Failures Among Patients Evaluated for Transcatheter Tricuspid Valve Repair (TriSelect-Study)
- Retrospective cohort study
- multicentre
Authors' conclusion
The majority of TTVr screen failure patients are excluded due to TV, right atrial, and RV enlargement. However, a significant proportion is excluded due to clinical futility.
Study context
- Population
- Patients evaluated for transcatheter tricuspid valve repair (TTVr) for tricuspid regurgitation (TR) at 3 centres in the US and Germany, January 2016 to December 2021
- Participants
- 547 patients · 3 centres
- Outcome
- Screen failure for TTVr: clinical characteristics and cardiac morphology
Main finding
As reported in the abstract
TTVr screening outcome and exclusion reasons
- Accepted for TTVr
- 58.1%
- Deemed unsuitable for TTVr
- 41.9%
- Exclusion reason among unsuitable: anatomical criteria
- 56.8%
- Exclusion reason: clinical futility
- 17.9%
- Exclusion reason: low symptom burden
- 12.7%
- Exclusion reason: technical limitations
- 12.7%
Observational data: associations, not effects.
Further findings
Management of excluded patients
- Conservative medical therapy
- 71.6%
- Tricuspid valve (TV) surgery
- 22.3%
- Later eligible for transcatheter TV replacement in US clinical trials
- 6.1%
Baseline characteristics
- Median age, years (IQR 74-83)
- 80
- Female
- 60.0%
Original publication
Characterization of Screen Failures Among Patients Evaluated for Transcatheter Tricuspid Valve Repair (TriSelect-Study). JACC Cardiovasc Interv. Published 10 July 2023. doi:10.1016/j.jcin.2023.03.036
Summarised from the published abstract; every number is checked against it