Characterization of sedation strategies in real-world use of pulsed field ablation Sub-analysis of the EU-PORIA registry

doi:10.1093/europace/euaf287

Arrhythmias & electrophysiologySecondary analysis

Characterization of sedation strategies in real-world use of pulsed field ablation Sub-analysis of the EU-PORIA registry

EuropacePublished 17 Nov 2025

Secondary analysis of the EU-PORIA registry
all-comer registry
consecutive patients
7 high-volume European centres

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Authors' conclusion

AF ablation using deep sedation with the pentaspline PFA catheter demonstrated a safety and efficacy profile consistent with procedures performed under general anesthesia.

Study context

Population: Patients undergoing atrial fibrillation (AF) ablation with the pentaspline pulsed field ablation (PFA) catheter
Participants: 1,233 patients

Comparison: Deep sedation vs General anesthesia
Deep sedationn = 983
General anesthesian = 250reference

Primary result

As reported in the abstract

Freedom from recurrent AF/atrial tachycardia (AT) (episode >30s) · 1 year

General anesthesia74.8%

Deep sedation73.8%

P = 0.87

Further findings

PVI-only

P < 0.01

General anesthesia72%

Deep sedation90%

3D mapping use

P < 0.01

General anesthesia60%

Deep sedation27%

Procedure time · spread printed in brackets, kind not stated

P < 0.01

General anesthesia75 minrange 60–90

Deep sedation51 minrange 36–84

Fluoroscopy time · spread printed in brackets, kind not stated

P < 0.01

General anesthesia19 minrange 15–26

Deep sedation13 minrange 8–19

Safety

Serious adverse events

No differences in incidence of serious adverse events

Original publication

Characterization of sedation strategies in real-world use of pulsed field ablation Sub-analysis of the EU-PORIA registry. Europace. Published 17 November 2025. doi:10.1093/europace/euaf287

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Summarised from the published abstract; every number is checked against it