Characterizing cardiac adipose tissue in post-acute myocardial infarction patients via CT imaging: a comparative cross-sectional study
Main finding · Non-culprit PVAT mean attenuationResult — go to the resultDifference 8.01 HU 95% CI 5.90–10.11Authors' conclusion
Post-AMI patients showed higher PVAT and EAT attenuation than stable CAD patients, potentially indicating AMI-associated inflammatory cardiac adipose tissue changes. A total of -70 HU can act as a potential cut-off for inflamed EAT. These findings highlight the potential of using CT-derived adipose tissue characteristics to assess inflammation and guide post-AMI management strategies.
Study context
- Population
- Post-treatment acute myocardial infarction (AMI) patients and stable coronary artery disease (CAD) patients
- Participants
- 205 vs 205
- Exposure
- post-AMI patients vs stable CAD patients
- post-AMI patientsn = 205
- Stable CAD patientsn = 205
- Outcome
- Non-culprit PVAT mean attenuation
Methodological detailspropensity-matched
- Propensity-matched
Main finding
As reported in the abstract
Difference
8.01 HU
95% CI 5.90–10.11
P < 0.001
post-AMI patientsvs stable CAD patients
difference 8.01 HU (95% CI 5.90–10.11); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Difference (HU) (95% CI) | P value | |
|---|---|---|---|
| EAT mean attenuation | 2.48 (0.83–4.13) | P = 0.003 | |
| −20246Difference, HU (linear scale) |
| Outcome | Difference (cm³) (95% CI) | P value | |
|---|---|---|---|
| EAT volume percentage at higher attenuation levelspost-AMI patientsvs stable CAD patients | 33.93 (16.86–51.00) | P < 0.001 | |
| −50050100Difference, cm³ (linear scale) |
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| EAT volume percentage at higher attenuation levelspost-AMI patientsvs stable CAD patients | 4.75% (3.64%–5.87%) | P < 0.001 | |
| −50510Difference (linear scale) |
- Epicardial adipose tissue (EAT) volume percentage at higher attenuation levels: difference maximized at the −70 HU threshold; higher in post-AMI patients
Correlation of perivascular adipose tissue (PVAT) mean attenuation with EAT mean attenuations and percentage of EAT volume > −70 HU
- PVAT mean attenuation positively correlated with EAT mean attenuations and the percentage of EAT volume > −70 HU
- P < 0.001 for both
Original publication
Characterizing cardiac adipose tissue in post-acute myocardial infarction patients via CT imaging: a comparative cross-sectional study. Eur Heart J Cardiovasc Imaging. Published 17 January 2025. doi:10.
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