Cholesterol Management Gaps Among Patients With Established Coronary Artery Disease Hospitalized for Acute Coronary Events
Main finding · LDL-C <70 mg/dL at admissionResult — go to the resultAdjusted prevalence ratio 1.96 95% CI 1.84–2.08Authors' conclusion
Targeted quality improvement initiatives are needed to address gaps in ambulatory cholesterol management.
Study context
- Population
- Adults ≥18 years of age with coronary artery disease (CAD) hospitalized for myocardial infarction or unstable angina in 2023 to 202423,558 with documented low-density lipoprotein cholesterol (LDL-C) at admission
- Participants
- 34,003 adults
- Exposure
- Statin use vs no statin use for LDL-C <70 mg/dL at admission
Methodological detailsGet With The Guidelines-CAD registry
- Get With The Guidelines-CAD registry
Main finding
LDL-C <70 mg/dL at admission · admission
Adjusted prevalence ratio
1.96
95% CI 1.84–2.08
By group
Using statins vs not using statins
aPR 1.96 (95% CI 1.84–2.08)
As reported in the abstract
- Overall LDL-C <70 mg/dL among 23,558 patients with documented LDL-C at admission
- 42.6%
Observational data: associations, not effects.
Further findings
| Outcome | aPR (95% CI) | |
|---|---|---|
| LDL-C <70 mg/dL, women vs men — Women vs men · among those using statins | 0.85 (0.81–0.85) | |
| LDL-C <70 mg/dL, women vs men — Women vs men · among those not using statins | 0.79 (0.70–0.89) | |
| LDL-C <70 mg/dL, Black vs White patients using statins | 0.70 (0.65–0.75) | |
| 0.512Adjusted prevalence ratio (log scale) |
Lipid-lowering medication use at admission
- Using a statin
- 68.4%
- Using statins, ezetimibe, or proprotein convertase subtilisin/kexin type 9 inhibitors
- 71.1%
LDL-C <100 mg/dL and <55 mg/dL (secondary analyses)
- LDL-C <100 mg/dL
- 67.7%
- LDL-C <55 mg/dL
- 25.4%
Original publication
Cholesterol Management Gaps Among Patients With Established Coronary Artery Disease Hospitalized for Acute Coronary Events. JACC Adv. Published 3 September 2026. doi:10.
Summarised from the published abstract; every number is checked against it