Coronary disease & ACSCohort study
Chronic coronary syndromes without standard modifiable cardiovascular risk factors and outcomes: the CLARIFY registry
- Prospective cohort study
- registry
- multinational (45 countries)
Authors' conclusion
SMuRF-less patients with stable CAD have a substantial but significantly lower 5-year rate of CV death or non-fatal MI than patients with risk factors. The risk of CV outcomes increases steadily with the number of risk factors.
Study context
- Population
- Outpatients with stable coronary artery disease (CAD) enrolled 2009–2010 in 45 countries (CLARIFY)22,132 with complete data
- Participants
- 32,703 outpatients
- Exposure
- SMuRF-less vs patients with standard modifiable cardiovascular (CV) risk factors
- SMuRF-lessn = 977
- Outcome
- Composite of:
- CV death
- Non-fatal myocardial infarction (MI)
- Follow-up
- 5 years
Main finding
As reported in the abstract
CV death or non-fatal MI
P = 0.012
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality and MACE · 5 years
- Lower in SMuRF-less patients
Clinical events by number of SMuRFs
- Event rates increased steadily with the number of SMuRFs
Benefit of SMuRF-less status by sex (subgroup)
- Particularly pronounced in women
Original publication
Chronic coronary syndromes without standard modifiable cardiovascular risk factors and outcomes: the CLARIFY registry. Eur Heart J. Published 20 May 2024. doi:10.1093/eurheartj/ehae299
Summarised from the published abstract; every number is checked against it