Cardio-oncology & otherCohort study
Chronic Hypertension and Cardiovascular Disease After Preeclampsia: A Danish Nationwide Register-Based Cohort Study Identifying Women at High Risk
- Nationwide register-based cohort study
Authors' conclusion
Early-onset preeclampsia, smoking, co-existing diabetes, certain ethnic origins, lower educational level, higher maternal age at delivery, and pre-pregnancy BMI ≥ 25 kg/m2 were identified as risk factors for later chronic hypertension or CVD among women with preeclampsia.
Study context
- Population
- Primiparous women with preeclampsia who gave birth during 2004–2018, Danish nationwide registries
- Participants
- 17,434 women
- Outcome
- later chronic hypertension or CVD
Main finding
As reported in the abstract
Developed chronic hypertension
2,372
Developed cardiovascular disease (CVD)
373
Observational data: associations, not effects.
Further findings
Chronic hypertension
| Comparison | IRR (95% CI) | |
|---|---|---|
| smoking in pregnancy | 1.20 (1.05–1.36) | |
| gestational diabetes | 1.36 (1.19–1.56) | |
| pre-existing type 1 diabetes | 2.09 (1.57–2.78) | |
| type 2 diabetes | 1.47 (0.93–2.33) | |
| low education | 1.50 (1.31–1.72) | |
| 0.20.5125Incidence rate ratio (log scale) |
CVD
| Comparison | IRR (95% CI) | |
|---|---|---|
| smoking in pregnancy | 1.24 (0.86–1.80) | |
| gestational diabetes | 1.25 (0.80–1.94) | |
| pre-existing type 1 diabetes | 1.89 (0.77–4.59) | |
| type 2 diabetes | 1.47 (0.36–6.01) | |
| low education | 2.77 (1.92–3.98) | |
| 0.10.31310Incidence rate ratio (log scale) |
| Outcome | Values | Estimate |
|---|---|---|
| Early-onset preeclampsia, by later chronic hypertension status | later chronic hypertension 13.3% · no chronic hypertension 7.4% | |
| Early-onset preeclampsia, by later CVD status | later CVD 12.1% · no CVD 8.1% |
Region of origin, BMI, and age
- The regions with the highest IRR differed between outcomes, and IRs were higher than among Danish-born women for some regions and lower for others
- IRs also increased with higher BMI and age, more steeply above 25 kg/m² and 40 years
Original publication
Chronic Hypertension and Cardiovascular Disease After Preeclampsia: A Danish Nationwide Register-Based Cohort Study Identifying Women at High Risk. Eur J Prev Cardiol. Published 1 October 2026. doi:10.1093/eurjpc/zwag507
Summarised from the published abstract; every number is checked against it