Cardio-oncology & otherCohort study
Chronic kidney disease, proteinuria, and the risk of infective endocarditis in patients with diabetes: a nationwide retrospective cohort study
- Retrospective cohort study
- nationwide
- population-based
Authors' conclusion
CKD and proteinuria in the population with diabetes are associated with an increased risk of developing IE.
Study context
- Population
- Patients with DM who underwent a health checkup in 2009, Korean National Health Insurance Service database821 infective endocarditis (IE) cases
- Participants
- 866,918 patients
- Exposure
- Estimated glomerular filtration rate (eGFR) and dipstick proteinuria categories
- eGFR <60n = 107,746
- Outcome
- Development of infective endocarditis (ICD-10 I33.x, I38.x, I39.8 with hospitalisation >14 days or death within 14 days)
- Follow-up
- Median 12.3 years
Main finding
Infective endocarditis
Adjusted hazard ratio
1.357
95% CI 1.098–1.676
eGFR <60 vs eGFR ≥90
aHR 1.357 (95% CI 1.098–1.676)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Chronic kidney disease, proteinuria, and the risk of infective endocarditis in patients with diabetes: a nationwide retrospective cohort study. Eur J Prev Cardiol. Published 25 July 2025. doi:10.1093/eurjpc/zwaf430
Summarised from the published abstract; every number is checked against it