Chronic Kidney Disease Screening in Patients With Coronary Heart Disease: The Multinational INTERASPIRE Study
Authors' conclusion
Without UACR, half of those with CKD would remain undetected.
Study context
- Population
- Patients with coronary artery disease (CAD), assessed for estimated glomerular filtration rate (eGFR) and urinary albumin/creatinine ratio (UACR) 6 to 24 months after diagnosis (79.6% male; age 18–80 years)3,865 with complete data
- Participants
- 4,548 patients
- Exposure
- low-moderate vs high vs very high risk
- Outcome
- First of CV death, MI, stroke, and hospitalization for HF
- Follow-up
- Median 1 year
Methodological details14 countries, all WHO regions
- 14 countries, all WHO regions
Main finding
As reported in the abstract
CKD prevalence by KDIGO risk class
- Chronic kidney disease (CKD) (KDIGO) present
- 32%
- CKD undetected without UACR
- 51.3%
Observational data: associations, not effects.
Further findings
| Outcome | Low-moderate | High | Very high risk | |
|---|---|---|---|---|
| Primary event (CV death, MI, stroke, HF hospitalisation) · median 1 year | ||||
| Men | Not reported in the abstract | 13.0% | Not reported in the abstract | low-moderate, very high risk: not reported in the abstract |
| Women | Not reported in the abstract | 11.8% | Not reported in the abstract | low-moderate, very high risk: not reported in the abstract |
- Primary event (CV death, MI, stroke, HF hospitalisation) — Primary event, overall
- 7.9%
Primary event (CV death, MI, stroke, HF hospitalisation) · median 1 year
- Highest incidence in KDIGO high-risk group; independent of other risk factors
Original publication
Chronic Kidney Disease Screening in Patients With Coronary Heart Disease: The Multinational INTERASPIRE Study. J Am Coll Cardiol. Published 1 April 2026. doi:10.
Summarised from the published abstract; every number is checked against it