Coronary disease & ACSCohort study
Chronic PM2.5 Exposure Is Associated With Invasively Assessed Coronary Endothelial Dysfunction
- Prospective cohort study
- single-centre
- generalized propensity score with stabilized inverse probability weights
Authors' conclusion
Chronic PM2.5 exposure is associated with epicardial coronary ED, suggesting a potential biological link between PM2.5 and CAD.
Study context
- Population
- Patients with angina and nonobstructive coronary artery disease (CAD) undergoing coronary reactivity testing at Mayo Clinic, 2000–2023
- Participants
- 1,485 patients
- Exposure
- Chronic PM2.5 exposure
- Outcome
- Epicardial endothelial dysfunction (EED; <−20% change in coronary diameter in response to acetylcholine)
Main finding
EED per 1 μg/m3 increase in PM2.5
Odds ratio
1.078
95% CI 1.021–1.139
P = 0.007
PM2.5 per 1 μg/m3 increase
OR 1.078 (95% CI 1.021–1.139); P = 0.007
Per 1 μg/m3 increase, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
Characteristics of patients exposed to PM2.5 above EPA standards (9 μg/m3)
- Younger, fewer CV comorbidities, worse lipid profiles
Original publication
Chronic PM2.5 Exposure Is Associated With Invasively Assessed Coronary Endothelial Dysfunction. J Am Coll Cardiol. Published 20 May 2026. doi:10.1016/j.jacc.2026.03.155
Summarised from the published abstract; every number is checked against it