Arrhythmias & electrophysiology
CineECG analysis provides new insights into Familial ST-segment Depression Syndrome
Authors' conclusion
CineECG analyses indicated abnormal repolarization with basal directions, and the Fam-STD ECG phenotype was simulated by reducing APD and APA in the left ventricle basal regions. Detailed ST-analysis showed amplitudes consistent with the proposed diagnostic criteria for Fam-STD patients.
Study context
- Population
- Patients with Familial ST-segment Depression Syndrome (74% females, mean age 51.6 ± 6.2 years)
- Participants
- 27 vs 83
- Comparison
- Fam-STD patients vs matched controls
- Fam-STDn = 27
- Controlsn = 83reference
- Outcome
- Electrical activation pathway (CineECG, anterior-basal orientation) and ST-segment amplitudes in nine 10 ms subintervals, Fam-STD vs matched controls
Methodological detailsage- and sex-matched controls, computer simulation
- Age- and sex-matched controls
- Computer simulation
Main finding
As reported in the abstract
- Significantly abnormal activation direction toward basal areas of the heart, from QRS 60-89 ms until Tpeak-Tend, in Fam-STD
- all P < 0.001
- Significant ST-segment differences in all nine 10 ms subintervals, most prominent at 70-79/80-89 ms
- all P < 0.01
Observational data: associations, not effects.
Original publication
CineECG analysis provides new insights into Familial ST-segment Depression Syndrome. Europace. Published 4 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →