Arrhythmias & electrophysiologyMechanistic study
Circulating miR-10b-5p as a candidate biomarker of atrial fibrillation recurrence after catheter ablation: a two-phase translational study
- Two-phase translational study (discovery case-control and prospective validation cohort)
- machine learning
Authors' conclusion
Down-regulation of circulating hsa-miR-10b-5p was independently associated with AF recurrence after catheter ablation and improved risk discrimination beyond clinical variables.
Study context
- Population
- Patients undergoing catheter ablation for atrial fibrillation (AF)discovery n = 29
- Comparison
- Circulating miRNA expression in AF recurrence vs no recurrence after catheter ablation
- Outcome
- AF recurrence after catheter ablation
Main finding
As reported in the abstract
Prognostic performance of hsa-miR-10b-5p for AF recurrence (validation cohort)
hsa-miR-10b-5p AUC (highest discriminative performance)
0.96, P < 0.001
Lower hsa-miR-10b-5p expression, independent predictor of recurrence (multivariable logistic regression), OR
0.06, P < 0.001
Improvement over baseline clinical model, ΔR
63.3%
Further findings
Discovery phase: differential expression of 84 microRNAs (miRNAs)
- miRNAs significantly associated with AF recurrence
- 14
Pathway enrichment for hsa-miR-10b-5p
- Linked to FOXO signalling, p53 signalling, circadian rhythm and cellular senescence
Original publication
Circulating miR-10b-5p as a candidate biomarker of atrial fibrillation recurrence after catheter ablation: a two-phase translational study. Europace. Published 28 April 2026. doi:10.1093/europace/euag097
Summarised from the published abstract; every number is checked against it