Heart failure & cardiomyopathiesCohort study
Circulating Neutrophil-Related Proteins Associate with Incident Heart Failure and Cardiac Dysfunction: The ARIC Study
- Prospective cohort study
Authors' conclusion
Plasma proteins related to neutrophil function associate with incident HF in mid- and late-life and with adverse cardiac remodelling.
Study context
- Population
- ARIC cohort participants at Visit 3 (1993–1995; mean age 60 ± 6 years, 54% women) and Visit 5 (2011–2013; mean age 75 ± 5 years, 57% women)
- Exposure
- Per 1-SD increase in protein-based neutrophil activity score
- Outcome
- Incident heart failure (HF); cardiac function
Main finding
As reported in the abstract
Incident HF
neutrophil activity scoreHazard ratio (95% CI)
per 1-SD increase; mid-life (Visit 3)
1.31(1.25–1.37)
per 1-SD increase; late-life (Visit 5)
1.23(1.14–1.34)
Per 1-SD increase, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident HF by type: HFpEF vs HFrEF — neutrophil activity score · per 1-SD increase; HFpEF | 1.30 (1.16–1.47) | |
| Incident HF by type: HFpEF vs HFrEF — neutrophil activity score · per 1-SD increase; HFrEF | 1.13 (0.98–1.30) | |
| 0.512Hazard ratio (log scale) |
Cardiac structure and function
- Higher neutrophil activity associated with greater LV end-diastolic volume index, mass index and diastolic and systolic dysfunction
Original publication
Circulating Neutrophil-Related Proteins Associate with Incident Heart Failure and Cardiac Dysfunction: The ARIC Study. Eur J Heart Fail. Published 17 October 2023. doi:10.1002/ejhf.3008
Summarised from the published abstract; every number is checked against it