Classification and Outcomes of Coronary Microvascular Disease in Myocardial Infarction and Angina With Nonobstructive Coronary Arteries
- prospectively enrolled and retrospectively classified cohort
- invasive coronary function testing
- invasive provocation testing
+2 more
- invasive coronary function testing
- invasive provocation testing
Authors' conclusion
CMD is common in both MINOCA and ANOCA. The higher prevalence of endothelium-independent CMD in MINOCA suggests a potential mechanistic role in infarction. Patients with MINOCA have a worse prognosis than ANOCA, particularly when CMD is present.
Study context
- Population
- Patients with nonobstructive coronary arteries undergoing invasive coronary function testing from 2012 to 2022; myocardial infarction due to atherothrombosis, myocarditis, and Takotsubo syndrome excludedMINOCA 73 · ANOCA 549
- Participants
- 622 patients
- Exposure
- MINOCA compared with ANOCA
- MINOCAn = 73
- ANOCAn = 549reference
Main finding
As reported in the abstract
Coronary microvascular disease (CMD)
P = 0.271
Observational data: associations, not effects.
Further findings
Endothelium-independent CMD · more frequent in MINOCA
P < 0.001
Major adverse cardiovascular events · median follow-up of 4.5 years
adjusted hazard ratio 2.4 · P = 0.001
| Outcome | Hazard ratio (95% CI) | P value | |
|---|---|---|---|
| Major adverse cardiovascular events, CMD vs no CMD, within each group — CMD · MINOCA | 3.6 (1.1–12.0) | P = 0.038 | |
| Major adverse cardiovascular events, CMD vs no CMD, within each group — CMD · ANOCA | 7.9 (2.9–21.8) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Classification and Outcomes of Coronary Microvascular Disease in Myocardial Infarction and Angina With Nonobstructive Coronary Arteries. Circ Cardiovasc Interv. Published 15 October 2026. doi:10.
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Summarised from the published abstract; every number is checked against it