Heart failure & cardiomyopathiesCohort study
Clinical and cardiac magnetic resonance phenotype of probable viral vs probable immune-mediated acute myocarditis
- Cohort study
- two tertiary centres
Authors' conclusion
pVM and pIM were associated with distinct clinical and CMR phenotypes.
Study context
- Population
- Patients referred for cardiac magnetic resonance (CMR) for clinically suspected myocarditisreferred for CMR
- Participants
- 1,122 patients
- Exposure
- Probable immune-mediated vs probable viral acute myocarditis
- Probable viral myocarditis (pVM)n = 379reference
- pIMn = 116
- Outcome
- Composite of:
- First HF hospitalization
- Recurrent myocarditis
- Sustained VT
- All-cause death
- Follow-up
- Median 3.3 years
Main finding
Composite endpoint
Adjusted hazard ratio
1.89
95% CI 1.03–3.48
P = 0.041
pIM vs pVM
HRadj 1.89 (95% CI 1.03–3.48); P = 0.041
As reported in the abstract
Observational data: associations, not effects.
Further findings
Age
P < 0.001
Acute chest pain and ST-segment elevation
P = 0.012
Late gadolinium enhancement
P = 0.006
Basal septal LGE involvement
P = 0.006
Predictors of adverse events (within groups)
- In pIM, age was the only predictor of adverse events; in pVM multiple clinical and CMR features were prognostically relevant
Original publication
Clinical and cardiac magnetic resonance phenotype of probable viral vs probable immune-mediated acute myocarditis. Eur J Heart Fail. Published 18 June 2026. doi:10.1093/ejhf/xuag202
Summarised from the published abstract; every number is checked against it